protac brd4 degrader-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13833	PROTAC BRD4 Degrader-1		Epigenetic Reader Domain
	PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).		Epigenetic Reader Domain
T18598	PROTAC BRD2/BRD4 degrader-1		Others
	PROTAC BRD2/BRD4 degrader-1 (compound 15) serves as a potent, selective degrader of BET proteins BRD4 and BRD2, achieving rapid, reversible, and unexpectedly selective elimination of BRD4 and BRD2 compared to BRD3. Its e...		Others
T18603	PROTAC BRD4 degrader for PAC-1		Others
	PROTAC BRD4 degrader for PAC-1 (compound 5) is a chimeric BET degrader GNE-987 conjugated with a disulfide-containing linker[1]. This PROTAC-linker conjugate specifically targets and degrades BRD4, enabling selective pro...		Others
T5436	MZ 1		Epigenetic Reader Domain
	MZ 1 is a BRD4 protein degrader based on PROTAC technology.		Epigenetic Reader Domain
T14408	Azido-PEG1-CH2CO2H		Others , PROTAC Linker
	Azido-PEG1-CH2CO2H is a PROTAC linker that refers to an alkyl/ether combination. Azido-PEG1-CH2CO2H can be used to synthesize PROTAC BRD4 Degrader-1[1].		Others , PROTAC Linker
T5435	ARV-771		Epigenetic Reader Domain
	ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively[1].		Epigenetic Reader Domain
T36242	PROTAC BRD4 Degrader-5	PROTAC BRD4 Degrader-5
	PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].
T36628	PROTAC BRD4 Degrader-8	PROTAC BRD4 Degrader-8
	PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells...
T17477	Azido-PEG1-CH2COO-Cl		Others
	Azido-PEG1-CH2COO-Cl (compound 43a) is an alkyl/ether-based PROTAC linker, commonly employed in the synthesis of PROTAC BRD4 Degrader-1[1].		Others
T81386	PROTAC BRD4 Degrader-22		Epigenetic Reader Domain
	PROTAC BRD4 Degrader-22 (Compd 44h) is a PROTAC-based degrader targeting BRD4, exhibiting a pDC50 of 9.2 in MOLT4 cells over 24 hours [1].		Epigenetic Reader Domain
T75149	PROTAC BRD4 Degrader-19
	PROTAC BRD4 Degrader-19 (compound 176) is a proteolysis-targeting chimera (PROTAC) designed to specifically degrade the BRD4 protein, offering potential utility in cancer research [1].
T10522	BET-IN-6		Epigenetic Reader Domain
	BET-IN-6, a ligand with potent and high affinity for inhibiting BRD2/BRD4, plays a crucial role in the synthesis of PROTAC BRD2/BRD4 degrader-1 [1], targeting the protein BRD2/4.		Epigenetic Reader Domain
T74090	PROTAC BRD4 Degrader-7
	PROTAC BRD4 Degrader-7, a potent bromodomain BRD4 inhibitor exemplified by compound 1a, demonstrates half-maximal inhibitory concentrations (IC50s) of 15.5 nM and 12.3 nM for BRD4-BD1 and BRD4-BD2, respectively [1].
T79818	PROTAC BRD4 Degrader-21		Epigenetic Reader Domain
	PROTAC BRD4 Degrader-21 (Comp 74), a potent degrader of BRD4, has demonstrated substantial inhibition of tumor growth in mouse xenograft models, showing its potential for use in anticancer research [1].		Epigenetic Reader Domain
T18554	Pomalidomide-PEG1-azide		Others
	Pomalidomide-PEG1-azide is an E3 ligase ligand-linker conjugate that combines the cereblon ligand based on Pomalidomide with a linker. This compound is instrumental in designing PROTAC BRD4 Degrader-1[1].		Others
T18808	Thalidomide-NH-C4-NH2 TFA		Others
	Thalidomide-NH-C4-NH2 TFA (compound 29c) is a conjugate consisting of an E3 ligase ligand-linker, incorporating the Thalidomide-based cereblon ligand and a linker moiety. This compound, Thalidomide-NH-C4-NH2 TFA, is util...		Others
T78956	PROTAC BRD3/BRD4-L degrader-2		Epigenetic Reader Domain
	PROTAC BRD3/BRD4-L degrader-2, a PROTAC molecule, selectively degrades cellular BRD3 and BRD4-L with K i values of 16.91 and 2.8 nM, respectively, and exhibits robust antitumor activity in mouse xenograft models, serving...		Epigenetic Reader Domain
T78647	PROTAC BRD4 Degrader-16		PROTACs
	PROTAC BRD4 Degrader-16 is a potent degrader of BRD4, exhibiting IC50 values of 34.58 nM for BRD4 (BD1) and 40.23 nM for BRD4 (BD2). It significantly reduces Cyclin B1 expression, thereby impeding G2/M phase progression,...		PROTACs
T18067	Lenalidomide-PEG1-azide		Others
	Lenalidomide-PEG1-azide is an E3 ligase ligand-linker conjugate that incorporates the cereblon ligand based on Lenalidomide and a linker. It is designed for use in the development of PROTAC BRD4 Degrader-2[1].		Others
T74126	PROTAC BRD4 Degrader-14
	PROTAC BRD4 Degrader-14, a PROTAC (Proteolysis Targeting Chimera) linked by ligands to von Hippel-Lindau and BRD4, exhibits IC50 values of 1.8 nM and 1.7 nM for BRD4 BD1 and BD2, respectively. This compound effectively d...